Endocrine Abstracts

Hypothalamo-pituitary-adrenal (HPA) axis responses to stress are attenuated perinatally in mother rodents. We have now investigated the peripheral sympathetic and adrenal medulla responses to stress in pregnancy by measuring noradrenaline and adrenaline secretion after stress. Virgin and pregnant rats were blood sampled before and after exposure to airpuff startle stress in their home cages, and samples analysed for adrenaline, noradrenaline and ACTH concentration by RIA. Airp...

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

Background: Cushing’s disease is characterized by chronic ACTH hypersecretion, leading to hyperplasia of the adrenal zonae reticularis and fasciculata and, therefore, increased secretion of cortisol, androgens and DOC. Cushing’s disease is the most common form of Cushing’s syndrome, being responsible for approximately 80% of reported cases.Aim: To evaluate the curability rate of Cushing’s disease 1 year postoperatively.<p clas...

Introduction: Endogenous Cushing’s syndrome (CS) results from chronic excessive cortisol secretion. Discovering the source of disease is very important, but non-invasive tests cannot always be enough at the determination of correct location. We need more novel markers for distinguishing adrenal Cushing (AC) and pituitary Cushing (CD). We conducted this study for evaluating usefullness of preoperative DHEA-S levels at differentiating AC and CD.Materi...

Introduction: Nelson´s Syndrome is defined as the presence of an enlarging pituitary tumor associated with elevated fasting plasma ACTH levels and hyperpigmentation in patients submitted to bilateral adrenalectomy for the treatment of Cushing´s disease. Case Report: We present a case of a 48 y/o woman who in 2015, was diagnosed of Cushing’s disease and underwent transsphenoidal adenomectomy but remission was not achieved, so the patient wa...

Introduction: The auto immune’s diseases are also involved in the heart’s failure. Grave disease(GD) is an autoimmune thyroid disease that often linked by pericarditis. We report a case of an acute pericarditis that was also presumed to be associated with GD.Case report: A 59 years old who 10 pack years smoker. admitted for chest pain and shortness breathstage 3NYHA. At the investigation there was a progessive emaciation of 12 kg within 7 mon...

Autoimmune hypoadrenalism (Addison’s disease) is a rare condition with a European prevalence of up to 140 per million1. It frequently occurs in association with other organ-specific autoimmune diseases, both endocrine and non-endocrine. These conditions are recognised to occur in the extended family, but their prevalence has been hard to determine, because of the rarity of the disease.In 2003 we conducted the largest international survey ...

IntroductionGraves’ disease is typically characterized by the presence of circulating autoantibodies that stimulate the TSH receptor, inducing hyperthyroidism and goiter. Hashimoto’s thyroiditis is an autoimmune disease leading to thyroid tissue destruction by cell and antibody-mediated immune processes. The development of Hashimoto’s thyroiditis following Graves’ disease is rarely reported. Its pathogenesis is not confirmed. Herein, ...

Introduction: Cushing’s disease is caused by endogenous hypercotisolism, due to the hypersecretion of the adenocorticotropic hormone (ACTH) by an ACTH-secreting pituitary adenoma. However, some patients with Cushing’s disease have no visible adenoma on MRI. The goal of this study is to review the clinical features, diagnosis and medical preparation of patients with Cushing’s disease.Material and Methods: A retrospective study including ...

A 47-year-old female presented with facial swelling, easy bruising, and concern regarding possible Cushing’s syndrome. She had developed secondary amenorrhoea 3 years previously; biochemistry suggested hypogonadotrophic hypogonadism, felt to be hypothalamic secondary to low BMI and intense exercise. She was normotensive, and BMI was 17.4. There was no evidence of abdominal striae, proximal myopathy or hirsutism, but her face appeared rounder and plethoric compared with a ...